Published April 2014 | Version v1
Journal article Metadata-only

The experimental study of the potential radioprotectors - S-(azaheteryl) substituted cysteamine

Creators

  • 1. DU Yinstitut Medichnoyi Radyiologyiyi, NAMN Ukrayini, Kharkyiv (Ukraine)
  • 2. Zaporyiz'kij Natsyional'nij Unyiversitet, MON Ukrayini, Zaporyizhzhya (Ukraine)

Description

Experimentally the radioprotective activity of the compounds synthesized from a number of S-(azageteril) substituted cysteamine in acute radiation injury of the body was studied. Experiments were carried out on the nonlinear mature white male rats weighing 160-180 g, which were irradiated with X-ray machine RUM-17 under standard conditions in absorbed dose of 4.0; 5.5; 6.2 and 8.5 Gy. High radioprotective activity of hydrochloride-S-(6-ethoxy-2-methyl-quinolin-4-yl)-cysteamine (compound KM51) in acute radiation injury of the body has revealed.

Additional details

Additional titles

Original title (Ukrainian)
Vivchennya v eksperimentyi potentsyijnikh radyioprotektoryiv - S-(azageteril) zamyishchenikh tsisteamyinu

Publishing Information

Journal Title
Ukrayins'kij Radyiologyichnij Zhurnal
Journal Volume
22
Journal Issue
no.2
Journal Page Range
p. 149-154
ISSN
1027-3204

Conference

Title
Scientific-Practical conference UTRO 'Actual questions of radiation oncology in Ukraine'
Original Conference Title
Naukovo-praktichna Konferentsyiya UTRO 'Aktual'nyi pitannya radyiatsyijnoyi onkologyiyi v Ukrayinyi'
Dates
30 Jun - 1 Jul 2014
Place
Kharkyiv (Ukraine)

INIS

Country of Publication
Ukraine
Country of Input or Organization
Ukraine
INIS RN
46024085
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ACUTE IRRADIATION; BIOLOGICAL RADIATION EFFECTS; CYSTEAMINE; MALES; RADIATION DOSES; RADIATION INJURIES; RADIOPROTECTIVE SUBSTANCES; RATS; X RADIATION
Descriptors DEC
ACUTE EXPOSURE; AMINES; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DISEASES; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; INJURIES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; THIOLS; VERTEBRATES