Definition of the microelemental contents in endometrium and hair of patients with various forms of infertility

Full text: Research of human's endometrium condition (a mucous membrane of a cavity of a uterus) is undoubtedly of interest for the solution of some problems of clinical medicine, in particular, infertility reasons. In spite of the fact that endometrium is one of the most accessible tissues to research, and the object of the numerous versatile researches, there are still many questions on its physiology and pathology, in particular, those connected with its preparation for implantation, processes of cellular interactions during implantation and placentation. Today the exclusive role of microcells (MC) in pathology development in human, since infantile age to old age is known. As a result of laborious researches it was possible to establish that MC are regulators of chemical processes of a metabolism, growth and reproduction, immunologic and hormonal activity, and life expectancy. In reproductology, the influence of the some people essential (vital) and toxic MC demands the further detailed studying. The purpose of the present research is studying microelement structure of endometrium and hair of women with various infertility forms, with the subsequent development of a technique aimed at correction of discovered microelementosis. We examined 20 patients with infertility. All patients apart from the traditional complex, general laboratory and endoscopic researches, passed the neutron-activation analysis of microelemental structure of endometrium and hair. The age of patients varied from 21 to 39 years. Duration of infertility (primary and secondary) has made up 3-11 years. The somatic status was complicated with diseases of digestion, endocrynologic, urinary, respiratory and cardiovascular systems, whereas the anemia was observed at 70 % of patients. Endoscopical examinations (laparo-, histero-, falloposcopy) have revealed presence of adhesive process of various degree of expressiveness in an abdominal cavity and a small basin cavity, peritubal adhesive process, various degree of expressiveness genital endometriosis, cysts, cystomas and polycysts ovaries, uterus myomas, various ethiology inflammatory diseases of uterus appendages. The contents of 9 essential (vital) (Fe, Zn, Cu, Mn, Mo, Co, Cr, Se, I), 2 conditionally-essential (Ni, Br), 5 potentially toxic (Rb, Ag, Au, Sr, Sc) and 3 toxic microcells (Ba, Hg, Sb), and also 5 macroelements (Ca, K, Na, Cl, Mg) in hair and endometrium of the examined patients is studied. Significant decrease in the contents of MC in hair of patients with infertility existing normative parameters (A.A.Kist, 1987; A.V. Skalnyi, I.A.Rudakov, 2004). Was observed the first data on contents of MC in endometrium are obtained for women with infertility, laws of contents of MC in hair and endometrium of the women, suffering infertility were searched and the screening-research for establishment of normative parameters was conducted. (author)