Study of peptides bioactivity synthesized on the basis of (S)-)-α-allylglycine non-protein amino acid

To identify peptides bioactivity, 2 di- and 4 tripeptides containing a non-protein amino acid (S)-α-allylglycine (2-aminopent-4-enovic acid) were synthesized. Microbiological studies have revealed that N-tert-butyloxycarbonyl-(S)-alanyl-(S)-)-α-allylglycine, N-tert-butyloxycarbonyl-(S)-alanyl-(S)-)-α-allylglycylglycine, N-tert-butyloxycarbonyl-(S)-alanyl-(S)-)-α-allylglycyl-(S)-alanine peptides suppress the growth of gram negative: E. coli, C. freundii, S. marcesens, S. typhimurinum, Erwinia sp., P. putida and gram positive B. flavum, B. lactofermentum, B. subtilis strains. The studied peptide N-tert-butyloxycarbonylglycyl-(S)-)-α-allylglycyl glycine is an inhibitor of the branched-chain amino acid aminotransferases