Published 1980 | Version v1
Journal article Metadata-only

Effects of selective ultraviolet phototherapy (SUP) and local PUVA treatment on DNA synthesis in Guinea pig skin

Creators

  • 1. Koeln Univ. (Germany, F.R.). Hautklinik

Description

The treatment with UV-light with wavelengths between 292.5-335 nm (known as selective UV-phototherapy, or SUP) and 320-390 nm (plus local treatment with 8-methoxypsoralen, known as PUVAsub(ex)) gave rise to a biphasic reaction of epidermal cell proliferation in guinea pig skin. A decrease of proliferative activity was followed by a synchronized stimulation of DNA synthesizing cells after 2-4 h. These quantitative displacements were accompanied by qualitative changes in the proliferative behaviour of epidermal cells in the S-compartment. (orig.)

Abstract (German)

Exposition von UV-Licht mit den Wellenlaengen 292,5-335 nm (selektive UV-Phototherapie; SUP) und 320-390 nm (plus lokaler Behandlung mit 8-Methoxypsoralen; PUVAsub(ex)) fuehrte in der Meerschweinchen-Haut zu einer biphasischen Reaktion der epidermalen Zellproliferation. Im Anschluss an eine verminderte Proliferationsaktivitaet setzte eine synchronisierte Stimulationswelle von DNS synthetisierenden Zellen nach 2-4 h ein. Neben diesen quantitativen Verschiebungen traten qualitative Veraenderungen im Proliferationsverhalten epidermaler Zellen innerhalb des S-Kompartments auf. (orig.)

Additional details

Publishing Information

Journal Title
Arch. Dermatol. Res.
Journal Volume
267
Series
Arch. Dermatol. Res.
Journal Page Range
37-45

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
12575613
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOSYNTHESIS; CELL PROLIFERATION; DNA; EPIDERMIS; GUINEA PIGS; RADIOTHERAPY; ULTRAVIOLET RADIATION
Descriptors DEC
ANIMALS; BODY; ELECTROMAGNETIC RADIATION; EPITHELIUM; MAMMALS; MEDICINE; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATIONS; RODENTS; SKIN; SYNTHESIS; THERAPY; TISSUES; VERTEBRATES