Change of the Serum Composition in Irradiated Mice

This study is aimed to investigate the change of serum compositions of mice caused by the irradiation. The 3 Gy radiation with 10 MeV Linac was once irradiated to whole body of mice and their serum was collected to conduct 14 biochemical analyses. With the collected data, t-test was performed. As the result, the significant change was confirmed in the following 3 compositions. First, the glucose level of the normal control group was 185.43±14.93, but the irradiation group was found to be 220.00±17.58, which shows significant difference(p<0.001). Second, the BUN(blood urea nitrogen) measurement showed lower value(15.70±1.48) in the irradiation group than the normal control group(19.61±1.65), which indicates the significant difference in mean value (p<0.01). Third, the measurement of albumin resulted in lower value of 2.89±0.25 in irradiation group than 3.19±0.25 of the normal control group, which shows the significant difference in mean value(p<0.05). In consequence, the serum of the mice irradiated with 3 Gy radiation caused significant change in 3 compositions; glucose, Blood urea nitrogen(BUN) and albumin.