Published December 2019 | Version v1
Journal article Metadata-only

A luminescent Zn(II) coordination polymer for selective detection of Fe3+ ion that reverses the resistance of ovarian cancer to cisplatin

Creators

  • 1. Southeast University, Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine (China)
  • 2. The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University (China)
  • 3. Southeast University, Department of Pediatrics, Zhongda Hospital, School of Medicine (China)

Description

By using the π-electron-rich organic ligand biphenyl-3,4′,5-tricarboxylic acid (H3BPT), the three-dimensional coordination polymer [Zn4(μ4-H2O)Cl2(BPT)2](DMF)2 was successfully prepared by the reaction of H3BPT and Zn(NO3)2·6H2O in the presence of HCl as the pH modulator under solvothermal conditions. The sensing as well as fluorescence properties of the coordination polymer were studied in detail, showing the selective quenching response that was highly efficient for the Fe3+ ion. In the activity research section, we firstly evaluate the promotion effects of the compound on the efficacy of cisplatin against HO-8910/DDP cancer cells with CCK-8 assay, as well as the IC50 calculation. Next, to explore the relative mechanism, the reverse transcription polymerase chain reaction was performed and the mdr1 and mdr3 genes relative expression was measured. The results obtained through molecular docking and pose scoring software exhibited a possible binding mode of the compound binding to Bcl2, which might provide potential regulation mechanisms for the compound. Graphic abstract:

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Additional details

Identifiers

DOI
10.1007/s00706-019-02519-y;

Publishing Information

Journal Title
Monatshefte fuer Chemie
Journal Volume
150
Journal Issue
12
Journal Page Range
p. 2029-2036
ISSN
0026-9247
CODEN
MOCHAP

INIS

Country of Publication
Austria
Country of Input or Organization
Austria
INIS RN
52059621
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S60: APPLIED LIFE SCIENCES;
Descriptors DEI
BIPHENYL; CHAIN REACTIONS; COMPUTER CODES; DIMETHYLFORMAMIDE; FLUORESCENCE; HYDROCHLORIC ACID; IRON IONS; LIGANDS; NEOPLASMS; NITRATES; NITROGEN OXIDES; OVARIES; POLYMERASE CHAIN REACTION; POLYMERASES; POLYMERS; QUENCHING; SENSORS; TRANSCRIPTION; WATER; ZINC COMPLEXES
Descriptors DEC
AMIDES; AROMATICS; BODY; CHALCOGENIDES; CHARGED PARTICLES; CHLORINE COMPOUNDS; COMPLEXES; DISEASES; EMISSION; ENZYMES; FEMALE GENITALS; GENE AMPLIFICATION; GONADS; HALOGEN COMPOUNDS; HYDROCARBONS; HYDROGEN COMPOUNDS; INORGANIC ACIDS; INORGANIC COMPOUNDS; IONS; LUMINESCENCE; NITROGEN COMPOUNDS; NUCLEOTIDYLTRANSFERASES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; PHOTON EMISSION; PROTEINS; TRANSFERASES

Optional Information

Copyright
Copyright (c) 2019 Springer-Verlag GmbH Austria, part of Springer Nature