An experimental study on the acute effects of high dose irradiation on rats

In case of occurring the atomic energy accident, the proper medical control measures should be necessary but little is known till now. For the first step of studies on acute effect of high dose level irradiation, preliminary experimental studies were carried-out evaluate the physiological changes in Wistar rat by irradiation. The results were summarized as follows: 1. The leukocyte count in the peripheral blood after irradiation was significantly decreased and approved one of most sensitive physiological changes by irradiation. 2. After irradiation, the erythrocyte count and hematocrit ratio were also decreased but not so remarkable as leukocyte count depletion. 3. The concentration of sodium ion in serum was not changed noticeably but the concentration of potassium ion and calcium ion were decreased by irradiation. 4. The total volume of daily urine output was also decreased especially in male rat by irradiation. (Author)