Published 1990 | Version v1
Report Metadata-only

Effect of antibody concentration on polymeric antibody formation by cyclic DTPA dianhydride reaction and relationship between polymer formation and immunoreactivity of antibody

Creators

  • 1. National Inst. of Health, Bethesda, MD (United States)
  • 2. George Washington Univ., Washington, DC (United States)

Description

The conjugation of DTPA to antibody using cyclic DTPA dianhydride (cDTPAA) produces cross linked antibody-DTPA polymers in addition to monomeric antibody-DTPA dependent upon the concentrations of antibody and cDTPAA. The purpose of this research was to investigate the effect of antibody concentration on the polymer formation and the relationship between the polymer formation and the immunoreactivity of antibody

Additional details

Publishing Information

Imprint Title
Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
Imprint Pagination
458 p.
Journal Page Range
p. 317.
Report number
DOE/ER/60968--1

Conference

Title
8. international symposium on radiopharmaceutical chemistry.
Dates
24-29 Jun 1990.
Place
Princeton, NJ (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
23031434
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
ALBUMINS; ANTIBODIES; BIOCHEMICAL REACTION KINETICS; CHEMICAL REACTION KINETICS; DTPA; GLYCINE; INDIUM CHLORIDES; INDIUM COMPLEXES; INDIUM 111; LIQUID COLUMN CHROMATOGRAPHY; POLYMERIZATION; POLYMERS; QUANTITY RATIO; SILICA GEL; THIN-LAYER CHROMATOGRAPHY
Descriptors DEC
ADSORBENTS; AMINO ACIDS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; CHEMICAL REACTIONS; CHLORIDES; CHLORINE COMPOUNDS; CHROMATOGRAPHY; COMPLEXES; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HALIDES; HALOGEN COMPOUNDS; INDIUM COMPOUNDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; REACTION KINETICS; RESPONSE MODIFYING FACTORS; SEPARATION PROCESSES

Optional Information

Secondary number(s)
CONF-9006363--Absts.