Evaluation in the baboon model of 99mTc-biguanide as a tracer for renal imaging

Studies in various animal species have recently shown that 99mTc-BIG has practical and dosimetric benefits for renal imaging that could probably make it a good alternative to 99mTc-2,3-dimercaptosuccinic acid (99mTc-DMSA). In this study, using the baboon experimental model, the biodistribution of 99mTc-BIG and 99mTc-DMSA are compared. It is demonstrated that early good contrast imaging and more favourable dosimetry is possible with 99mTc-BIG compared to 99mTc-DMSA, confirming the quoted previous findings with small animals. Time-activity curves for kidneys and other organs support these findings, and MIRDOSE software provided the dosimetry