Published 1990 | Version v1
Report Metadata-only

Z-11β-chloromethyl-17α-iodovinyl estradiol, a very high affinity estrogen for radioimaging and targetted radiotherapy of estrogen receptor (ER) positive tumors

Creators

  • 1. Inst. Bordet, Bruxelles (Belgium)
  • 2. Medgenix S.A., Fleurus (Belgium)

Description

The authors have synthesized iodine-123 and iodine-125 labelled Z-11β-chloromethyl-17α-iodovinyl estradiol for the purpose of imaging and therapy of estrogen receptor containing tumoral tissues. They have used these radiopharmaceuticals to conduct binding studies, to determine in vitro cytotoxicity and biodistribution patterns in mice and rats

Additional details

Publishing Information

Imprint Title
Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
Imprint Pagination
458 p.
Journal Page Range
p. 454-455.
Report number
DOE/ER/60968--1

Conference

Title
8. international symposium on radiopharmaceutical chemistry.
Dates
24-29 Jun 1990.
Place
Princeton, NJ (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
23029854
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
ANIMAL CELLS; ANTIMITOTIC DRUGS; BONE MARROW; CHEMICAL PREPARATION; CYTOPLASM; DIAGNOSTIC TECHNIQUES; DNA; ESTRADIOL; ESTROGENS; HALOGEN COMPOUNDS; IN VITRO; IODINE 123; LABELLING; MICE; MOLECULAR STRUCTURE; NEOPLASMS; ORGANIC CHLORINE COMPOUNDS; PROTEINS; RADIOPHARMACEUTICALS; RADIOTHERAPY; RATS; RECEPTORS; TISSUE DISTRIBUTION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CELL CONSTITUENTS; DISEASES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ESTRANES; HEMATOPOIETIC SYSTEM; HORMONES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MEDICINE; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; STEROID HORMONES; STEROIDS; SYNTHESIS; THERAPY; TISSUES; VERTEBRATES

Optional Information

Secondary number(s)
CONF-9006363--Absts.