Radiofrequency ablation combined with ¹²⁵I radioactive seed implantation for the treatment of liver cancer: analysis of curative effect

Objective: To evaluate the clinical effect of radiofrequency ablation (RFA) combined with ¹²⁵I radioactive seed implantation in treating poor blood supply hepatic malignant tumors with diameter greater than 5 cm. Methods: The clinical data of 80 patients with poor blood supply hepatic malignant tumor, who received minimally-invasive interventional therapy from January 2013 to June 2016, were retrospectively analyzed. According to the therapeutic method, the patients were divided into the combination group (n = 47, receiving RFA plus ¹²⁵I radioactive seed implantation) and thecontrol group (n = 33, receiving simple transcatheter arterial chemoembolization). The curative effect, overall survival (OS) and adverse reactions were compared between the two groups. Results: The objective remission rate (ORR) and the disease control rate (DCR) in the combination group were 87.2%and 95.7% respectively, which were remarkably higher than 66.7% and 81.8% respectively in the control group, the differences were statistically significant (P < 0.05). The one-year survival rate in the combination group was 80.9%, which was significantly higher than 75.8% in the control group (P < 0.05). Conclusion: For the treatment of poor blood supply hepatic malignant tumors with diameter greater than 5 cm, RFA combined with ¹²⁵I radioactive seed implantation has a good clinical effect. It can improve the ORR and the DCR, and prolong the patient's short-term and mid-term survival time. (authors)