Published November 1988 | Version v1
Journal article Metadata-only

Radiosensitivity of chromosomes in two successive mitotic cycles of human lymphocytes

Creators

  • 1. Scientific-Research Institute of Medical Radiology, Obninsk (USSR)

Description

A culture of human lymphocytes was irradiated with γ-quanta in a dose of 0.5 Gy with different ratios of cells in first (M1) and second (M2) mitotic cycle and the frequency of aberrations induced at stage G2 was analyzed. With increase in interval of time between the start of culturing and irradiation, total yield of aberrations increased in a regular way. However, if the M1:M2 ratio is considered, then it turns out that in M2 chromosomes are ∼1.5 times more sensitive than in M1: within the limits of each cycle, radiosensitivity is constant and does not depend on its duration. It was established in accordance with data of other authors that 5-bromodeoxyuridine (5-BdU) increases radiosensitivity materially

Additional details

Publishing Information

Journal Title
Soviet Genetics (English Translation)
Journal Volume
24
Journal Issue
5
Series
Sov. Genet. (Engl. Transl.).
Journal Page Range
586-590
ISSN
0038-5409
CODEN
SOGEB

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
20084346
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BROMOURACILS; CELL CULTURES; CHROMATIDS; CHROMOSOMAL ABERRATIONS; CHROMOSOMES; COBALT 60; COLCHICINE; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; GENETIC RADIATION EFFECTS; LYMPHOCYTES; MAN; MITOSIS; MUTATION FREQUENCY; NUCLEOSIDES; RADIOSENSITIVITY; RADIOSENSITIZERS; UPTAKE
Descriptors DEC
ALKALOIDS; ANIMAL CELLS; ANIMALS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; ANTIPYRETICS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CELL DIVISION; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESS; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; DRUGS; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKOCYTES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; MUTATIONS; NUCLEI; NUCLEOTIDES; ODD-ODD NUCLEI; ORGANIC BROMINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PRIMATES; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RIBOSIDES; SOMATIC CELLS; URACILS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
Translated from Genetika; 24: No. 5, 842-847(May 1988). Cover-to-cover translation of Genetika (USSR).