Published May 2001 | Version v1
Journal article Metadata-only

Synthesis and tissue distribution in mice of 18F-FDG

Creators

  • 1. First Military Medical Univ., Guangzhou (China). Nanfang Hospital

Description

2-Deoxy-2-18F-fluoro-D-glucose (18F-FDG) was synthesized via nuclear reaction 18O(p, n)18F and nucleophilic substitution reaction by PET trace Cyclotron-FDG Synthesis System. The corrected radiochemical yield was about 54% and the radiochemical purity was above 95% by HPLC and TLC. The distribution of 18F-FDG in mice showed that the higher uptake rates of 18F-FDG in heart and brain were found, the radioactivity retained in heart and brain for longer time and the radioactivity in kidney was rapidly cleared. The radioactivity in blood and organs dropped very slowly 30 min after injection of 18F-FDG. The synthetic 18F-FDG allowed for PET study and diagnosis of patients

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
24
Journal Issue
5
Journal Page Range
p. 417-420
ISSN
0253-3219

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
32044474
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
DIAGNOSTIC TECHNIQUES; FLUORINE 18; GLUCOSE; NUCLEOSYNTHESIS; OXYGEN 18 TARGET; PROTON COMPUTED TOMOGRAPHY; PROTON REACTIONS; RADIOACTIVITY; TISSUE DISTRIBUTION
Descriptors DEC
ALDEHYDES; BARYON REACTIONS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOHYDRATES; CHARGED-PARTICLE REACTIONS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISTRIBUTION; FLUORINE ISOTOPES; HADRON REACTIONS; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOSACCHARIDES; NANOSEC LIVING RADIOISOTOPES; NUCLEAR REACTIONS; NUCLEI; NUCLEON REACTIONS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPES; SACCHARIDES; SYNTHESIS; TARGETS; TOMOGRAPHY