Immunoprotective and leukopoiesis-stimulating effects of 10-hydroxy-Δ2-decenoic acid in patients under radiotherapy
Creators
- 1. Suzhou Medical Coll., JS (China). First Affiliated Hospital
Description
10-Hydroxy-Δ2-decenoic acid(10-HDA) is an unique fatty acid component in royal jelly. It was used in randomized trials in 52 patients with malignant tumors. The synthesis of DNA in their T-lymphocytes induced by PHA was investigated by the determination of 3H-TdR incorporation. Comparison of preirradiation 'cpm' values between <60 Gy, 90∼100 Gy and >100 Gy dose groups showed no significant difference in degree of T-lymphocytes depression in the patients of treated groups. In the control group, however, 'cpm' values increased progressively with the increasing radiation dose. The results demonstrated that 10-HDA might have antiirradiation and immunoprotective effects during radiotherapy. It is concluded that 10-HDA is one of the safer and more effective adjuvant drugs in radiotherapy
Additional details
Publishing Information
- Journal Title
- Chin. J. Radiol. Med. Prot.
- Journal Volume
- 7
- Journal Issue
- 1
- Series
- Chin. J. Radiol. Med. Prot.
- Journal Page Range
- 40-42
- ISSN
- 0254-5098
- CODEN
- ZFYZD
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 19054838
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOSYNTHESIS; COBALT 60; DECANOIC ACID; DNA; GAMMA RADIATION; HYDROXY ACIDS; IMMUNITY; LEUKOCYTES; LYMPHOCYTES; NEOPLASMS; PATIENTS; RADIATION INJURIES; RADIATION PROTECTION
- Descriptors DEC
- ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; MINUTES LIVING RADIOISOTOPES; MONOCARBOXYLIC ACIDS; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; SOMATIC CELLS; SYNTHESIS; YEARS LIVING RADIOISOTOPES