I-131 labelled peanut lectin renal kinetics in cis-platin induced tubular toxicity in dogs

Quantitative I-131 labelled Peanut lectin (I-131-PNA) renal clearance was determined in dogs before and after a 5 day single cycle cis-platinum chemotherapy regimen (0.5mg/Kg/day). Results were statistically compared with E.R.P.F. (I-131-Hippuran), G.F.R. (Tc-99m-DTPA), and serum biochemistry and correlated with histopathology. I-131-PNA clearance was significantly reduced in all dogs 5 days after cessation of cis-platinum treatment (mean ΔS% = 71.3%) and similar reductions in the gamma camera derived renogram peak were demonstrated (mean ΔS% = 65.8%). E.R.P.F. was noted to drop by a minor degree (mean ΔS% = 20.9%) post treatment. G.F.R. was diminished (mean ΔS% = 46.6%) and serum creatinine elevated (mean ΔS% = 42.7%) in all dogs compared to their pretreatment values. Histopathology demonstrated variable degrees of tubular toxicity ranging from mild to severe. The degree of change of the I-131-PNA values was significantly greater than that predicted by indicators of glomerular function. These results suggest that quantitative renal tubular imaging may be useful in the determination of tubular toxicity