The application of elastase-induced carotid aneurysm rabbit models in interventional treatment of intracranial aneurysm and its research progress

New materials and technologies emerging in the endovascular treatment of intracranial aneurysms require reliable animal experiments before clinical application, which can not only effectively predict and reduce the occurrence of adverse events in clinical application, but also definitely guide and develop updated materials. The elastase-induced carotid aneurysm rabbit model is one of the most commonly used experimental models for testing the safety and effectiveness of newly-developed interventional materials. This paper aims to make a comprehensive review, focusing on the history of endovascular treatment of intracranial aneurysms, the development of elastase-induced carotid aneurysm model in rabbits, the superiority of this model to other animal models and its advantages in using new materials for preclinical trials, including histopathology, natural history, morphology, hemodynamic features, etc. The disadvantages of this model and its future development direction are also discussed. (authors)