Published November 1989 | Version v1
Journal article Metadata-only

An efficient, one-pot synthesis of 2-deoxy-2-[18F]fluoro-acetamido-D-glucopyranose (N-[18F]fluoroacetyl-D-glucosamine), potential diagnostic imaging agent

Creators

  • 1. Tohoku Univ., Sendai (Japan). Research Inst. for Tuberculosis and Cancer
  • 2. Tohoku Univ., Sendai (Japan). Cyclotron and Radioisotope Center

Description

A rapid, one-pot synthesis of 2-deoxy-2-[18F]fluoroacetamido-D-glucopyranose (N-[18F]fluoroacetyl-D-glucosamine) starting from [18F]fluoride and ethyl bromoacetate is described. The synthesis was accomplished by a combination of halogen exchange, alkaline hydrolysis, and condensation. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total synthesis time, the radiochemical yield, and purity are ca. 90 min, ca. 9.1%, and >98%, respectively. This sugar showed diagnostic tumor-imaging activity. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
27
Journal Issue
11
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1317-1324
ISSN
0362-4803
CODEN
JLCRD

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
22079852
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL PREPARATION; FLUORINE 18; HEXOSAMINES; LABELLING; NEOPLASMS; RADIOPHARMACEUTICALS
Descriptors DEC
AMINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOHYDRATES; DISEASES; DRUGS; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MONOSACCHARIDES; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SACCHARIDES; SYNTHESIS