Published June 13, 1986
| Version v1
Journal article
Transport of an intact oligopeptide across adult mammalian jejunum
Description
The passage of an intact nonapeptide across adult rabbit jejunum mounted in an Ussing Chamber is demonstrated with an HPLC system which resolves the renin inhibitor Pro-His-Pro-Phe-His-Leu-Phe-Val-[3H]Phe from all labelled proteolytic cleavage products. Permeability of the peptide (0.016 cm hr-1) is approximately one-seventh that observed for the actively transported 3-9-methyl glucose (0.104 cm hr-1). Flux of the peptide is not changed by the absence of sodium. This study shows that adult mammalian intestine can transport intact oligopeptides and suggests that it will be feasible to develop orally active peptide drugs
Additional details
Publishing Information
- Journal Title
- Biochem. Biophys. Res. Commun.
- Journal Volume
- 137
- Journal Issue
- 2
- Series
- Biochem. Biophys. Res. Commun.
- Journal Page Range
- 682-687
- ISSN
- 0006-291X
- CODEN
- BBRCA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18022790
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- ENZYME INHIBITORS; EXPERIMENTAL DATA; IN VITRO; INTESTINAL ABSORPTION; LIQUID COLUMN CHROMATOGRAPHY; PERMEABILITY; POLYPEPTIDES; PROTEOLYSIS; RABBITS; RENIN; SMALL INTESTINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS
- Descriptors DEC
- ANIMALS; BODY; CHEMICAL REACTIONS; CHROMATOGRAPHY; DATA; DECOMPOSITION; DIGESTIVE SYSTEM; ENZYMES; GASTROINTESTINAL TRACT; HYDROGEN COMPOUNDS; HYDROLASES; INFORMATION; INTESTINES; ISOTOPE APPLICATIONS; MAMMALS; NONSPECIFIC PROTEINASES; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HYDROLASES; PEPTIDES; PROTEINS; SEPARATION PROCESSES; UPTAKE; VERTEBRATES