Published 1995 | Version v1
Book Metadata-only

Reactions of thiols with individual DNA base radicals in DNA and DNA model systems: The effect of oxygen on radioprotection

Creators

  • 1. Oakland Univ., Rochester, MI (United States). Dept. of Chemistry

Description

Thiol radioprotection of DNA in the living cell has been suggested to be a result of hydrogen or electron donation to free radicals generated on DNA resulting in a repair of the original radical lesion. Thus far there are no reports of reactions of DNA anion radicals with thiols. Oxygen involvement in thiol free radical reactions has been implicated in oxygen radiosensitization of cells to the lethal effects of radiation. A biological oxygen enhancement effect and a chemical oxygen enhancement effect have both been recognized. One hypothesis is that thiyl radical reactions with oxygen are the source of the chemical oxygen enhancement effect

Additional details

Publishing Information

Publisher
Battelle Press.
Imprint Place
Columbus, OH (United States)
ISBN
0-935470-90-5
Imprint Title
Radiation damage in DNA: Structure/function relationships at early times
Imprint Pagination
460 p.
Journal Page Range
p. 111-119.

Conference

Title
relationships at early times.
Acronym
International workshop on radiation damage in DNA
Dates
1-6 Oct 1994.
Place
Gleneden, OR (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
28012756
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOCHEMICAL REACTION KINETICS; DNA REPAIR; GAMMA RADIATION; MOLECULAR BIOLOGY; OXYGEN; RADIATION PROTECTION; RADICALS; RADIOSENSITIVITY; THIOLS
Descriptors DEC
BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; ELECTROMAGNETIC RADIATION; ELEMENTS; IONIZING RADIATIONS; KINETICS; NONMETALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; REACTION KINETICS

Optional Information

Contract/Grant/Project number
Contract FG02-86ER60455
Secondary number(s)
CONF-9410280--.