Radiobiological effects induced by laser-accelerated protons

Recently, high-intensity laser ion acceleration has been suggested as a potential, cost-saving alternative technology to conventional accelerators for radiotherapy. In this review, investigations of the biological effects of the high bunch current and short bunch duration, that are typical of laser-acceleration, are reported. The radiobiological effects of high dose-rate irradiation with laser-driven proton beam are compared with those of beams derived from conventional ion accelerators. (author)