The relationship between P-selectin and intra-arterial restenosis after stenting

In endovascular interventional treatment the problem commonly encountered is the arterial restenosis due to vascular endothelial injury, thrombosis and intimal hyperplasia. In the process of arterial intimal hyperplasia, cell adhesion molecules may play an important role. The P-selectin, which is a significant element in adhesion molecules selectin family, is mainly expressed on the activated platelet and endothelial cell surface, and through starting cellular initial adhesion it is involved in early inflammation and wall reconstruction process after endovascular interventional treatment. (authors)