Published June 1987 | Version v1
Journal article Metadata-only

Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin

Creators

  • 1. Australian National Univ., Canberra

Description

The fungal metabolite gliotoxin at low concentrations prevents mitogen stimulation of mature lymphocytes as a result of gliotoxin-induced genomic DNA degradation. Bone marrow, on the other hand, contains a subpopulation of cells resistant to gliotoxin at similar concentrations. This population includes the hemopoietic progenitor cells that grow in vitro in response to appropriate colony-stimulating factors and cells that form colonies in the spleens of lethally irradiated recipients. Gliotoxin treatment of lymph node cell-enriched bone marrow significantly delayed the onset of graft-versus-host disease in fully allogeneic bone marrow chimeras

Additional details

Publishing Information

Journal Title
Proc. Natl. Acad. Sci. U.S.A
Journal Volume
84
Journal Issue
12
Series
Proc. Natl. Acad. Sci. U.S.A.
Journal Page Range
3822-3825
ISSN
0027-8424
CODEN
PNASA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
19058558
Subject category
S61: RADIATION PROTECTION AND DOSIMETRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL EFFECTS; BONE MARROW CELLS; CELL PROLIFERATION; COBALT 60; DECOMPOSITION; DNA; DNA REPLICATION; FUNGI; GAMMA RADIATION; GRAFT-HOST REACTION; INHIBITION; LETHAL IRRADIATION; LYMPHOCYTES; MICE; SPLEEN CELLS; THYMIDINE; TOXINS; TRITIUM COMPOUNDS
Descriptors DEC
ANIMAL CELLS; ANIMALS; ANTIGENS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHEMICAL REACTIONS; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKOCYTES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACID REPLICATION; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PLANTS; PYRIMIDINES; RADIATIONS; RADIOISOTOPES; RIBOSIDES; RODENTS; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES