Published August 2013
| Version v1
Journal article
Determinate the BPA in biological samples by spectrophotometry
- 1. Department of Isotopes, China Institute of Atomic Energy, Beijing (China)
Description
Boron neutron capture therapy (BNCT) is a new radiation therapy, of which clinical interest has focused primarily on the treatment of high-grade gliomas. At present, the most effective drug for BNCT is p-Boronophenylalanine (BPA), because it has little side effect and low toxicity, persisted longer in tumors compared with related molecules. The method of 3-Methoxy-Methylenimine H spectrophotometry was established to measure the concentration of 10B in biological samples. The biodistribution of the BPA was studied in normal mice. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Isotopes
- Journal Volume
- 26
- Journal Issue
- 3
- Journal Page Range
- p. 163-169
- ISSN
- 1000-7512
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 47057198
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANIMAL TISSUES; BORON; BORON 10; COMPARATIVE EVALUATIONS; CONCENTRATION RATIO; DRUGS; GLIOMAS; MICE; MOLECULES; NEUTRON CAPTURE THERAPY; ORGANIC BORON COMPOUNDS; PHENYLALANINE; SPECTROPHOTOMETRY; TISSUE DISTRIBUTION; TOXICITY
- Descriptors DEC
- AMINO ACIDS; ANIMALS; AROMATICS; BODY; BORON ISOTOPES; CARBOXYLIC ACIDS; DIMENSIONLESS NUMBERS; DISEASES; DISTRIBUTION; ELEMENTS; EVALUATION; ISOTOPES; LIGHT NUCLEI; MAMMALS; MEDICINE; NEOPLASMS; NERVOUS SYSTEM DISEASES; NEUTRON THERAPY; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOLOGY; RADIOTHERAPY; RODENTS; SEMIMETALS; STABLE ISOTOPES; THERAPY; VERTEBRATES
Optional Information
- Notes
- 5 figs., 5 tabs., 15 refs.