Published 1985 | Version v1
Journal article Metadata-only

NK cell activite in C157BL/Ka mice during the development of radiation induced thymic lymphomas

Creators

  • 1. Universite de Liege, Institut de Pathologie (Belgium)

Description

Treatment of C57BL/Ka mice with a split dose whole-body irradiation (four weekly irradiations of 1,75 Gy) induces the development of thymic lymphomas. NK activity of spleen cells has been determined at several internals after leukemogenic treatment. Two days after irradiations, NK activity is normal and decreases strongly after one week. This period of decline persists during about one month. Then, NK activity restores and reaches control values. Lymphomas appear in spite of NK activity restauration. The diminution of NK activity during the preleukemic period could favour preleukemic cells apparition

Abstract (French)

Le traitement de souris C57BL/Ka par une irradiation corporelle totale fractionnee (quatre irradiations de 1,75 Gy exercees a une semaine d'intervalle) induit le developpement de lymphomes thymiques. L'activite NK des cellules spleniques a ete determinee a differents intervalles apres ce traitement leucemogene. Deux jours apres les irradiations, l'activite NK est normale et diminue fortement apres une semaine. Cette periode de declin persiste pendant environ un mois. L'activite NK se retablit alors et atteint des valeurs analogues a celles des temoins. Des lymphomes paraissent malgre une restauration de l'activite NK. La diminution de l'activite NK durant la periode preleucemique pourrait favoriser l'apparition de cellules preleucemiques

Additional details

Additional titles

Original title (French)
Activite NK chez la Souris C57BL/Ka au cours du developpement des lymphomes radio-induits

Publishing Information

Journal Title
C. R. Seances Soc. Biol. Fil.
Journal Volume
179
Journal Issue
2
Series
C. R. Seances Soc. Biol. Fil.
Journal Page Range
271-275
ISSN
0037-9026

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
16080445
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; FRACTIONATED IRRADIATION; IMMUNITY; LYMPHOMAS; MICE; SPLEEN CELLS; THYMUS; WHOLE-BODY IRRADIATION; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; DISEASES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; LYMPHATIC SYSTEM; MAMMALS; NEOPLASMS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES