Published June 1987 | Version v1
Journal article Metadata-only

Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene

Creators

  • 1. Cornell Univ. Graduate School of Medical Sciences, New York, NY

Description

C3H/10T 1/2 cells were infected with a retroviral vector expressing a mouse c-myc oncogene and a drug-selection marker. The resulting cells, morphologically indistinguishable from C3H/10T l/1, displayed a greatly enhanced sensitivity to neoplastic transformation by ionizing radiation or by a chemical carcinogen. Constitutive expression of myc therefore appears to synergize with an initial carcinogenic event, providing a function analogous to a subsequent event that apparently is required for the neoplastic transformation of these cells. This cell system should prove useful in exploring early stages in radiation-induced transformation

Additional details

Publishing Information

Journal Title
Proc. Natl. Acad. Sci. U.S.A
Journal Volume
84
Journal Issue
12
Series
Proc. Natl. Acad. Sci. U.S.A.
Journal Page Range
4131-4134
ISSN
0027-8424
CODEN
PNASA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
19058206
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CESIUM 137; DOSE-RESPONSE RELATIONSHIPS; ELECTROPHORESIS; FIBROBLASTS; GAMMA RADIATION; HYBRIDIZATION; LABELLED COMPOUNDS; MICE; ONCOGENES; ONCOGENIC TRANSFORMATIONS; PHOSPHORUS 32; RADIATION EFFECTS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CESIUM ISOTOPES; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; ELECTROMAGNETIC RADIATION; GENES; INTERMEDIATE MASS NUCLEI; IONIZING RADIATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; PHOSPHORUS ISOTOPES; RADIATIONS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES