Enhanced radiation damage to iododeouridine-labelled cells
- 1. Swedish Univ. of Agriculture Sciences, Uppsala
Description
An investigation was made of the appearance of DNA damage and survival of IUdR-labelled CHO cells irradiated with gamma (sup 137 Cs) or soft X-rays (75 kV). The absorbed dose and radiation quality were measured using an ionization chamber and thermoluminescent dosemeter. Results show that there was a dose-dependent decrease in the survival of cells after irradiation with gamma or soft X-rays. In both cases the survival of IUdR-labelled cells was less than that of control cells. They yield of strand breaks increased linearly with doses up to a maximum of 6 Gy for gamma rays and 4 Gy for X-rays. After gamma irradiation the capacity of cells to repair DNA breaks was slower in IUdR-containing cells than in control cells. The potential of photon activation for improvement of radiotherapy is discussed
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Additional details
Publishing Information
- Imprint Title
- Workshop on photon activation therapy: proceedings
- Journal Page Range
- p. 25-34.
- Report number
- BNL--51997
Conference
- Title
- Workshop on photon activation therapy.
- Dates
- 18 Apr 1985.
- Place
- Upton, NY (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 21031248
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference, Numerical Data
- Descriptors DEI
- AUGER EFFECT; CELL CULTURES; CESIUM 137; CHO CELLS; DNA; DNA REPAIR; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; IODODEOXYURIDINE; RADIATION EFFECTS; RADIATION QUALITY; RADIOACTIVATION; RADIOTHERAPY; SOFT X RADIATION; STRAND BREAKS; SURVIVAL CURVES; THERMOLUMINESCENT DOSEMETERS; UPTAKE; X-RAY DOSIMETRY
- Descriptors DEC
- ANIMAL CELLS; ANTIMETABOLITES; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; CESIUM ISOTOPES; DATA; DOSEMETERS; DOSIMETRY; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INFORMATION; INTERMEDIATE MASS NUCLEI; IODOURACILS; IONIZING RADIATIONS; ISOTOPES; LUMINESCENT DOSEMETERS; MEASURING INSTRUMENTS; MEDICINE; NUCLEI; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATIONS; RADIOISOTOPES; RIBOSIDES; SOMATIC CELLS; THERAPY; URACILS; X RADIATION; YEARS LIVING RADIOISOTOPES