Published September 2017 | Version v1
Journal article Metadata-only

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Creators

  • 1. Institut Curie, INSERM U1021/CNRS UMR3347, Université Paris-Saclay, Orsay (France)
  • 2. Department of Radiation Oncology/DO/CHUV, Lausanne University Hospital (Switzerland)
  • 3. Institute of Radiation Physics (IRA), Lausanne University Hospital (Switzerland)
  • 4. Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (Switzerland)

Description

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2017.05.003

Additional details

Identifiers

DOI
10.1016/j.radonc.2017.05.003;
PII
S0167-8140(17)30365-1;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
124
Journal Issue
3
Journal Page Range
p. 365-369
ISSN
0167-8140
CODEN
RAONDT

Conference

Title
15. international Wolfsberg meeting
Dates
17-19 Jun 2017
Place
Wolfsberg (Switzerland)

INIS

Country of Publication
Ireland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
49072522
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BRAIN; DOSE RATES; GY RANGE 01-10; GY RANGE 10-100; IRRADIATION; MICE; RADIATION DOSES; RADIOTHERAPY; TOXICITY
Descriptors DEC
ABSORBED DOSE RANGE; ANIMALS; BODY; CENTRAL NERVOUS SYSTEM; DOSES; GY RANGE; MAMMALS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIATION DOSE RANGES; RADIOLOGY; RODENTS; THERAPY; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.