Nonnegative Gaussian process tomography for generalized segmented planar detectors

The concept of Gaussian process tomography along with nonnegative constraints is applied in the context of high-resolution image reconstruction using segmented planar detectors with few readout channels. Expanding on the concept of 2-D projections onto strip-like readout segmentations, 3-D projections as well as more generalized detector segmentation and readout channel mappings are explored. A focus is placed on reconstructing dose distributions in proton therapy pencil beam scanning, and a fast, approximate approach to applying nonnegative constraints is developed and motivated for use in proton therapy beam imaging.