Published December 18, 2013
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Innovative complexation strategies for the introduction of short-lived PET isotopes into radiopharmaceuticals
Description
A number of TRAP (Triazacyclononane-triphosphinate) chelators were evaluated for labelling with Gallium-68. Based on the obtained data, a novel bifunctional chelator NOPO was designed, synthesised and employed for preparation of Ga-68 radiopharmaceuticals. Several 68Ga-labelled NOPO peptidic conjugates showed promising results in preclinical positron emission tomography (PET) imaging studies using the mice models. Moreover, NOPO was found also suitable for labelling with Copper-64.
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Additional details
Publishing Information
- Imprint Pagination
- 122 p.
- Report number
- INIS-DE--1816
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 46045243
- Subject category
- S07: ISOTOPES AND RADIATION SOURCES; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Thesis
- Descriptors DEI
- CHELATING AGENTS; COPPER 64; GALLIUM 68; GALLIUM 71; GALLIUM COMPLEXES; GERMANIUM 68; LABELLING; MICE; NMR SPECTRA; PHOSPHINIC ACIDS; PHOSPHORUS 31; POSITRON COMPUTED TOMOGRAPHY; RADIOACTIVATION; RADIOPHARMACEUTICALS; SYNTHESIS; TRACER TECHNIQUES
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPLEXES; COMPUTERIZED TOMOGRAPHY; COPPER ISOTOPES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVEN-EVEN NUCLEI; GALLIUM ISOTOPES; GERMANIUM ISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; PHOSPHORUS ISOTOPES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SPECTRA; STABLE ISOTOPES; TOMOGRAPHY; VERTEBRATES