Published 1984
| Version v1
Journal article
Effects of oxygen and misonidazole on cell transformation and cell killing in C3H 10T1/2 cells by X rays in vitro
- 1. Atomic Energy of Canada Ltd. Research Co., Pinawa, Manitoba
Description
The effects of oxygen (air) and misonidazole on the transformation and killing of 10T1/2 cells by X rays were examined. The oxygen effect for the cell transformation end point was very similar to that for cell killing. Misonidazole enhanced both cell killing and cell transformation to a similar extent. The enhancement of both end points by misonidazole occurred only in the absence of oxygen during irradiation and was of lesser magnitude than that observed for oxygen. These results demonstrate that the radiation chemical processes leading to cell killing and cell transformation, respectively, are affected similarly by these two enhancers of radiation action. 22 references, 3 figures, 2 tables
Additional details
Publishing Information
- Journal Title
- Radiat. Res.
- Journal Volume
- 100
- Series
- Radiat. Res.
- Journal Page Range
- 96-103
- ISSN
- 0033-7587
- CODEN
- RAREA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17016347
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- ANIMAL CELLS; CELL KILLING; EXPERIMENTAL DATA; IN VITRO; MISONIDAZOLE; ONCOGENIC TRANSFORMATIONS; OXYGEN; RADIATION EFFECTS; RADIOSENSITIVITY; SURVIVAL CURVES; X RADIATION
- Descriptors DEC
- ALCOHOLS; ANTINEOPLASTIC DRUGS; AZOLES; DATA; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; INFORMATION; IONIZING RADIATIONS; NITRO COMPOUNDS; NONMETALS; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATIONS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS