Salicylic acid failed to increase the efficacy of Ca-DTPA in the decorporation of plutonium and americium
Description
Male and female C57BL/Do mice were each given a single ip injection of /sup 237 + 239/Pu + 241Am as the citrate complex at 45 days of age. Twice-weekly ip injections of either 500 μmole/kg Ca-DTPA or 500 μmole/kg Ca-DTPA mixed just before injection with 2000 μmole/kg salicylic acid (SA) were begun 3 days after nuclide administration and continued for 5 weeks. Control mice were injected each time with isotonic saline. Nuclide retention was determined by in vivo γ-ray counting using a NaI(Tl) crystal spectrometer. At the end of treatment, total-body retention of Pu or Am in the mice given Ca-DTPA was significantly lower (P < 0.001) than that in the control animals. Mice treated with Ca-DTPA plus SA were statistically indistinguishable from mice treated with Ca-DTPA alone
Additional details
Publishing Information
- Journal Title
- Radiat. Res.
- Journal Volume
- 84
- Journal Issue
- 1
- Series
- Radiat. Res.
- Journal Page Range
- 149-151
- ISSN
- 0033-7587
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 12591687
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- AMERICIUM 241; CALCIUM COMPOUNDS; DTPA; EXCRETION; EXPERIMENTAL DATA; GAMMA DETECTION; INTRAPERITONEAL INJECTION; MICE; PLUTONIUM 237; PLUTONIUM 239; RADIONUCLIDE KINETICS; RETENTION; SALICYLIC ACID; SYNERGISM; TIME DEPENDENCE; WHOLE-BODY COUNTING
- Descriptors DEC
- ACTINIDE NUCLEI; ALKALINE EARTH METAL COMPOUNDS; ALPHA DECAY RADIOISOTOPES; AMERICIUM ISOTOPES; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; CLEARANCE; COUNTING TECHNIQUES; DATA; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HEAVY NUCLEI; HYDROXY ACIDS; INFORMATION; INJECTION; INTAKE; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MAMMALS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PLUTONIUM ISOTOPES; RADIATION DETECTION; RADIOISOTOPES; RODENTS; SECONDS LIVING RADIOISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES