Acid phosphatase activity following hyperthermia of mouse spleen and its implication in heat potentiation of x-ray damage
Description
A quantitative histochemical assay has been used to investigate the effects of hyperthermia on lysosomal acid phosphatase activity in mouse spleen. The results showed a rapid increase in activity which was dependent on the increase in temperature. The activity level returned to normal within about 24 hr, the time course being similar to the decay in thermal enhancement ratio of some tissues for x rays given with time after heating. The variation in enzyme activity observed corresponded very well with the potential thermal enhancement of radiation damage with respect to both temperature dependence and the temporal relationship between heating and irradiation. These results suggest an involvement of lysosomal enzyme activation in the transient ability of hyperthermia to potentiate x-ray damage
Additional details
Identifiers
- DOI
- 10.2307/3574564;
Publishing Information
- Journal Title
- Radiation Research
- Journal Volume
- 72
- Journal Issue
- 1
- Series
- Radiat. Res.
- Journal Page Range
- 145
- ISSN
- 0033-7587
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 9382615
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACID PHOSPHATASE; BIOLOGICAL RADIATION EFFECTS; METABOLISM; MICE; RADIOSENSITIVITY; SPLEEN; TEMPERATURE DEPENDENCE; THERMAL SHOCK; X RADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BODY; ELECTROMAGNETIC RADIATION; ENZYMES; ESTERASES; HYDROLASES; IONIZING RADIATIONS; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PHOSPHATASES; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES
Optional Information
- Notes
- Updated automatically by Metadata and Full-Text Enrichment Agent