Normal distribution of 111In-bleomycin on scintigram

Bleomycin labelled with 111In was used as a tumor-localizing agent in 36 patients (40 scintigrams), who were suspected of or clinically diagnosed as having malignant tumor. All patients were inpatients or outpatients of the department of Radiology, University of Tokyo. The sites where there was clinically suspected malignant disease and where there was an abnormal accumulation on scintigrams were excluded in estimating the normal distribution of 111In-BLM. All scintigrams were taken 48 hrs after injection of 111In-BLM 2 - 3 mCi. The score of normal distribution was as follows: liver 100, mediastinum 54.0, thyroid area 50.0, nasopharynx 48.5, salivary area 42.5, lumbar spine 40.5 and kidney 30.5. The large intestine, hip joints, eye area and lung fields were revealed in a few cases. Comparing this study with the previous study on normal distribution of 67Ca-citrate, the score of large intestine was shown to be 28.5 - 37 points on 67Ga-citrate scintigrams, but it was only 1.5 - 0 points on 111In-BLM scintigrams. The kidneys were not appreciated on 67Ga-citrate scintigrams, but its score was 31.5 on 111In-BLM scintigrams. On the chest, the heart was not revealed on 67Ga-citrate scintigrams, but its score was 37.5 on 111In-BLM scintigrams. We conclude that 111In-BLM would be more effective than 67Ga-citrate in detecting malignant tumors which locate in lower abdomen. (auth.)