Published September 2021 | Version v1
Journal article Metadata-only

Impact of effective dose to immune cells (EDIC) on lymphocyte nadir and survival in limited-stage SCLC

Creators

  • 1. Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan (China)
  • 2. School of Medicine, Shandong University, Jinan (China)
  • 3. Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland (United States)
  • 4. Department of Radiation Oncology, Seidman Cancer Center, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland (United States)
  • 5. Department of Clinical Oncology, Hong Kong University Li Ka Shing Medical School, Hong Kong University Shenzhen Hospital, Hong Kong/Shenzhen (China)

Description

Highlights: • EDIC significantly correlated with lymphocyte nadir during thoracic radiotherapy. • Lymphocyte nadir and EDIC were independent factors for survival outcome in LS-SCLC. EDIC appear to have a better survival prediction accuracy than lymphocyte nadir. • More attention should be paid to EDIC to avoid circulating lymphocyte toxicity. Effective dose to immune cell (EDIC), an estimated radiation dose to the circulating lymphocytes, is of significance for overall survival (OS) in non-small cell lung cancer. This study aimed to validate the EDIC's OS effect on limited-stage small cell lung cancer (LS-SCLC).

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2021.06.020

Additional details

Identifiers

DOI
10.1016/j.radonc.2021.06.020;
PII
S0167814021065920;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
162
Journal Page Range
p. 26-33
ISSN
0167-8140
CODEN
RAONDT

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54014100
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACCURACY; EFFECTIVE RADIATION DOSES; LUNGS; LYMPHOCYTES; NEOPLASMS; RADIOTHERAPY; TOXICITY
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; DOSES; LEUKOCYTES; MATERIALS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATION DOSES; RADIOLOGY; RESPIRATORY SYSTEM; SOMATIC CELLS; THERAPY

Optional Information

Copyright
Copyright (c) 2021 Published by Elsevier B.V.