Published 2019 | Version v1
Journal article Metadata-only

Development of biological models and related detectors for ion-beam therapy

Creators

  • 1. National Institutes for Quantum and Radiological Science and Technology, National Institute of Radiological Sciences, Department of Accelerator and Medical Physics, Chiba (Japan)

Description

Carbon beams, used for cancer therapy, are characterized by rapidly changing radiation qualities as well as dose. This is significantly different from ordinary types of radiation. As a result, the biological effect and treatment efficacy change and actually increase around an end point. Therefore, a reliable biological model is indispensable for safe and efficient therapy. This article describes the development and character of the NIRS biological model, and compares it with the GSI biological model. Further development of various detectors for measuring the radiation qualities is outlined. (author)

Availability note (English)

Available from DOI: https://doi.org/10.3769/radioisotopes.68.367

Abstract (Japanese)

炭素線は従来の放射線と異なり,線量のみならず線質が照射野内で劇的に変化し,これに伴って生物・臨床効果も飛程終端に向けて高まる。安全で効果的な炭素線治療の実現のためには,線質の変化を生物効果と対応付けるための生物効果モデルの確立が不可欠である。本稿では,炭素線治療の実現のため放射線医学総合研究所で開発された日本式の生物モデルの進展を中心に,ドイツモデルとの比較や,治療ビームの線量・線質を測定するために開発されてきた検出器開発の概要を俯瞰する。(著者)

Additional details

Additional titles

Original title (Japanese)
炭素線治療のための生物モデルの進展と検出器の開発

Identifiers

DOI
10.3769/radioisotopes.68.367;

Publishing Information

Journal Title
Radioisotopes (Online)
Journal Volume
68
Journal Issue
6
Journal Page Range
p. 367-375
ISSN
1884-4111

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
52108380
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ABSORBED RADIATION DOSES; BIOLOGICAL MODELS; BRAGG CURVE; CELL NUCLEI; CLINICAL TRIALS; FAST NEUTRONS; HIMAC ACCELERATOR; ION BEAM THERAPY; LET; NEOPLASMS; PARTICLE BEAMS; RADIATION DOSE DISTRIBUTIONS; RBE; SURVIVAL CURVES; THERAPEUTIC DOSES
Descriptors DEC
ACCELERATORS; BARYONS; BEAMS; CELL CONSTITUENTS; CYCLIC ACCELERATORS; DIAGRAMS; DISEASES; DOSES; ELEMENTARY PARTICLES; ENERGY TRANSFER; EXTERNAL BEAM RADIATION THERAPY; FERMIONS; HADRONS; HEAVY ION ACCELERATORS; INFORMATION; MEDICINE; NEUTRONS; NUCLEAR MEDICINE; NUCLEONS; RADIATION DOSES; RADIOLOGY; RADIOTHERAPY; SYNCHROTRONS; TESTING; THERAPY

Optional Information

Notes
29 refs., 4 figs.