Published July 1999 | Version v1
Journal article Metadata-only

The effect of Essentiale on histones and nucleic acids in liver and blood-forming tissues of rats irradiated with γ-rays

Creators

  • 1. P.J. Safarik Univ, Kosice (Slovakia)

Description

Influence of the hepatoprotective drug Essentiale on the target (normal and regenerating liver) and the non-target (spleen and bone marrow) rat tissues was studied after whole body irradiation at the dose of 5.7 Gy γ-radiation. Application of the drug 24 h before irradiation alleviated all the radiation induced changes of the histones and nucleic acids in the normal and regenerating liver tissue. In the non-target tissues only mild radioprotective effect was observed. Application of the preparation 30 min after irradiation was less effective than the application before irradiation. Repeated application of Essentiale after irradiation did not increase the beneficial effect of the previous preparation application

Abstract (Russian)

В статье изучали влияние гепатопротекторного лекарственного средства Эссенциале на ткани-мишени (нормальная и регенерированная печень) и не-мишени (селезенка и костный мозг) крыс после общего γ-облучения в дозе 5.7 Гр. Применение лекарства за 24 ч до облучения ослабляет радиационно-индуцированные изменения гистонов и нуклеиновых кислот в нормальной и регенерированной печени. В тканях не-мишенях наблюдали лишь слабый радиопротекторный эффект. Применение препарата через 30 мин после облучения было менее эффективным, чем применение перед облучением. Повторное применение Эссенциале после облучения не увеличивало положительный эффект предварительного введения препарата

Additional details

Publishing Information

Journal Title
Radiatsionnaya Biologiya, Radioehkologiya
Journal Volume
39
Journal Issue
4
Journal Page Range
p. 388-393
ISSN
0869-8031
CODEN
RBIREJ

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
32019895
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BONE MARROW; DRUGS; GAMMA RADIATION; HISTONES; LIVER; NUCLEIC ACIDS; RADIATION DOSES; RADIOPROTECTIVE SUBSTANCES; RATS; SPLEEN; WHOLE-BODY IRRADIATION
Descriptors DEC
ANIMAL TISSUES; ANIMALS; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GLANDS; HEMATOPOIETIC SYSTEM; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIATION EFFECTS; RADIATIONS; RESPONSE MODIFYING FACTORS; RODENTS; VERTEBRATES

Optional Information

Notes
22 refs., 3 figs., 3 tabs.