Published 1992 | Version v1
Book Metadata-only

Tissue, cellular, and subcellular distribution of indium radionuclides in the rat

Creators

  • 1. Univ. of Lund (Sweden)
  • 2. Univ. of Uppsala (Sweden). Dept. of Toxicology

Description

The tissue distribution of 111In-activity in rat organs after intravenous injections of different 111In-radiopharmaceuticals have been studied by autoradiography. Quantitation was performed utilizing an image analyzing system designed for local measurements on whole-body autoradiographs. Additional studies of the cellular and subcellular localization in testes and bone marrow were performed by light and electron microscopy autoradiography after injection of 114mIn. The whole-body autoradiographs demonstrated a marked inhomogeneous radionuclide distribution in various tissues (e.g. kidneys, spleen, liver, bone marrow, lymph nodes and testes). In the testes it was observed by light microscopy autoradiography that the activity was localized in a significant concentration in the interstitial tissue, and to a minor amount in the periphery of the seminiferous tubules, coincident with the location of the radiosensitive spermatogenic cell lineage. In electron microscope autoradiographs subcellular localization sites appeared near and within the cell nucleus of spermatogonial cells, and also close to mitochondria. Similar results were found in the bone marrow. 85 refs

Additional details

Publishing Information

Publisher
American Inst. of Physics, Inc.
Imprint Place
Woodbury, NY (United States)
ISBN
1-56396-095-8
Imprint Title
Biophysical aspects of Auger processes. American Association of Physicists in Medicine symposium proceedings No. 8
Imprint Pagination
426 p.
Journal Page Range
p. 249-272.

Conference

Title
2. international symposium on biophysical aspects of Auger processes.
Dates
5-6 Jul 1991.
Place
Amherst, MA (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
26040636
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AUGER EFFECT; BIOLOGICAL MODELS; INDIUM 111; INDIUM 114; ISOMERIC NUCLEI; ORGANS; RADIONUCLIDE KINETICS; TISSUE DISTRIBUTION
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MILLISEC LIVING RADIOISOTOPES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES

Optional Information

Secondary number(s)
CONF-9107281--.