Published April 1989 | Version v1
Journal article Metadata-only

Testing of methyleneiminodiacetic-catechol and other aromatic chelating agents for decorporation of 238Pu and 241Am in rats

Creators

  • 1. Kernforschungszentrum Karlsruhe G.m.b.H. (Germany, F.R.). Inst. fuer Genetik und Toxikologie von Spaltstoffen

Description

The removal of 238Pu and 241Am by five chelating agents prepared in China was compared in pilot experiments with removal by Ca-DTPA and LICAM(C). The most promising substance is quinamic acid (a methyliminodiacetic poly-quinoline derivative, code name 811 or 703-73), especially in combination with Ca-DTPA. However, the best over-all reduction of both 238Pu and 241Am in all the organs studied was achieved by Ca-DTPA administered at a ten-fold human equivalent dosage. (author)

Additional details

Publishing Information

Journal Title
International Journal of Radiation Biology
Journal Volume
55
Journal Issue
4
Series
Int. J. Radiat. Biol.
Journal Page Range
679-688
ISSN
0020-7616
CODEN
IJRBA

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
20056095
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
AMERICIUM 241; CALCIUM COMPLEXES; CHELATING AGENTS; CLEARANCE; COMPARATIVE EVALUATIONS; DTPA; PLUTONIUM 238; PYROCATECHOL; QUINOLINES; RATS
Descriptors DEC
ACTINIDE NUCLEI; ALKALINE EARTH METAL COMPLEXES; ALPHA DECAY RADIOISOTOPES; AMERICIUM ISOTOPES; AMINO ACIDS; ANIMALS; AROMATICS; AZINES; CARBOXYLIC ACIDS; COMPLEXES; DEVELOPERS; DRUGS; EVALUATION; EVEN-EVEN NUCLEI; HEAVY NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; PLUTONIUM ISOTOPES; POLYPHENOLS; PYRIDINES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; SPONTANEOUS FISSION RADIOISOTO; VERTEBRATES; YEARS LIVING RADIOISOTOPES