Published 1983 | Version v1
Journal article Metadata-only

Value of the detection of anti-HBc by radioimmunological assay in liver disease

Creators

  • 1. Faculte de Medecine Lyon Nord et Grange Blanche (France)
  • 2. Hopital de l'Hotel-Dieu, Lyon (France)

Description

Detection of anti-HBc by radioimmunossay was carried out on 1365 sera obtained from 947 liver disease patients. Anti-HBc always confirmed HBV infection in patients with HBs antigenemia. By contrast in the absence of detectable HBs Ag or anti-HBs, anti-HBc often becomes the only serological clue suggesting evidence of recent or ongoing HBV infection. Since anti-HBc may persist for prolonged period of time following acute HB infection only distinction between the IgG and IgM classes of anti-HBc may help to distinguish between persistant or past infection

Abstract (French)

La detection de l'anti-HBc a ete effectuee en dosage radio-immunologique a partir de 1365 serums provenant de 947 malades presentant une hepatopathie. Au cours des hepatites aigues et chroniques, la mise en evidence de l'anti-HBc simultanement a l'Ag HBs, n'apporte pas d'element nouveau quant a l'existence d'une contamination par le VHB. En revanche, la recherche del'anti-HBc prend toute sa valeur diagnostique dans la phase ou aucun autre marqueur serologique HBs/anti-HBs ne peut etre detecte. Dans ce cas, sa presence permet de faire la preuve d'une infection hepatique due au VHB; toutefois, il n'est pas possible d'eliminer une autre etiologie associee recente. Compte tenu de la persistance prolongee d'anti-HBc, seule la recherche fractionnee d'anti-HBc IgM est susceptible de preciser l'actualite de l'infection a VHB

Additional details

Additional titles

Original title (French)
Interet de la detection des anti-HBc en dosage radio-immonologique dans les hepatopathies

Publishing Information

Journal Title
Ann. Gastroenterol. Hepatol.
Journal Volume
19
Journal Issue
1
Series
Ann. Gastroenterol. Hepatol.
Journal Page Range
15-20
ISSN
0066-2070

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
14795914
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BLOOD SERUM; DIAGNOSIS; HEPATITIS; RADIOIMMUNOASSAY; VIRUSES
Descriptors DEC
BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; DIGESTIVE SYSTEM DISEASES; DISEASES; ISOTOPE APPLICATIONS; MATERIALS; MICROORGANISMS; PARASITES; TRACER TECHNIQUES