Antibacterial activity of flavan-3-ol derivative compound from dichloromethane extract of Artocarpus dasyphylla tree bark

Infectious disease is one of sources of high morbidity and mortality caused by bacteria. Artocarpus plant is biosource to discover compounds with interesting bioactivites. The objective of this study is to find antibacterial compound from nature by extraction, fractionation, identification, and antibacterial test of secondary metabolite from dichloromethane extract of Artocarpus dasyphylla tree bark. The dichloromethane extract was fractionated repeatedly using various chromatographic techniques. The secondary metabolite was identified of its molecular structure based on UV-Vis, IR, NMR spectral data and confirmed by comparation with the reference. The secondary metabolite was known as catechin or 5,7,3',4'-tetrahydroxyflavan-3β-ol. Antibacterial testing of cathecin against Escherechia coli and Staphylococcus aureus showed a low antibacterial activity. (paper)