Published June 1981
| Version v1
Journal article
Kinetics of sup(99m)Tc-EHDP administered by intramuscular injection in man and in experimental animals
Description
With the aim of assessing the kinetics of a diphosphonate administered by intramuscular injection, we have studied the behaviour of sup(99m)Tc-labelled 1-hydroxy-1, 1-diphosphonate in man and in experimental animals, after intramuscular injection. The curves of plasma and urine radioactivity were analyzed in a six-compartment kinetic model containing seven transition coefficients. The results show that the diphosphonate given by intramuscular injection is absorbed rapidly and completely. Therefore the possibility of using this way of administration should be considered in the pathological conditions in which diphosphonates are used as therapeutic agents. (orig.)
Abstract (German)
Mit dem Ziel, die Kinetik eines intramuskulaer zugefuehrten Diphosphonats zu bestimmen, haben wir beim Menschen und bei Versuchstieren das Verhalten von sup(99m)Tc-markiertem 1-Hydroxy-1, 1-diphosphonat nach intramuskulaerer Injektion untersucht. Die Radioaktivitaetskurven von Plasma und Urin wurden in einem kinetischen Sechs-Kompartiment-Modell mit sieben Transitionskoeffizienten analysiert. Die Ergebnisse zeigen, dass das intramuskulaer gegebene Diphosphonat schnell und vollstaendig resorbiert wird. Deshalb sollte die Moeglichkeit dieser Art der Zufuhr unter denjenigen pathologischen Bedingungen in Erwaegung gezogen werden, in denen Diphosphonate als Therapeutika benutzt werden. (orig.)Additional details
Publishing Information
- Journal Title
- Nuc Compact
- Journal Volume
- 12
- Journal Issue
- 3
- Series
- Nuc Compact.
- Journal Page Range
- 111-114
- ISSN
- 0344-3752
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 13671930
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD PLASMA; DOGS; INTRAMUSCULAR INJECTION; ISOMERIC NUCLEI; KINETICS; PATIENTS; RADIOACTIVITY; RADIOPHARMACEUTICALS; TECHNETIUM COMPOUNDS; TECHNETIUM 99; UPTAKE; URINE
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; BODY FLUIDS; DRUGS; HOURS LIVING RADIOISOTOPES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; WASTES; YEARS LIVING RADIOISOTOPES