Published 1990
| Version v1
Report
[C-11]-carazolol: A new labeled beta-adrenergic ligand
- 1. University Hospitals of Cleveland, OH (United States)
- 2. Case-Western Reserve Univ., Cleveland, OH (United States)
Description
The authors have prepared carbon-11 labelled carazolol, a high affinity ligand with a slow rate of dissociation from the receptor, for use in in vivo studies of beta-adrenergic receptors. Both the labelling process and preliminary biodistribution studies in mice are discussed. The in vivo data indicate a sufficient uptake of the compound for use in PET imaging
Additional details
Publishing Information
- Imprint Title
- Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
- Imprint Pagination
- 458 p.
- Journal Page Range
- p. 359-360.
- Report number
- DOE/ER/60968--1
Conference
- Title
- 8. international symposium on radiopharmaceutical chemistry.
- Dates
- 24-29 Jun 1990.
- Place
- Princeton, NJ (United States).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 23029816
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference, Non-conventional Literature
- Descriptors DEI
- ACETONE; BOROHYDRIDES; CARBAZOLES; CARBON 11; CHEMICAL PREPARATION; IN VIVO; LABELLED COMPOUNDS; LABELLING; LIGANDS; LIQUID COLUMN CHROMATOGRAPHY; MICE; MOLECULAR STRUCTURE; PRECURSOR; RECEPTORS; SILICON OXIDES; SYMPATHOMIMETICS; TISSUE DISTRIBUTION; UPTAKE
- Descriptors DEC
- ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; AZOLES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BORON COMPOUNDS; CARBON ISOTOPES; CHALCOGENIDES; CHROMATOGRAPHY; DISTRIBUTION; DRUGS; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; ISOTOPES; KETONES; LIGHT NUCLEI; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; RADIOISOTOPES; RODENTS; SEPARATION PROCESSES; SILICON COMPOUNDS; SYNTHESIS; VERTEBRATES
Optional Information
- Secondary number(s)
- CONF-9006363--Absts.