Biliary stenting combined with ¹²⁵I seed strip implantation for the treatment of malignant obstructive jaundice: analysis of curative effect

Objective: To investigate the curative effect of biliary stenting combined with ¹²⁵I seed strip implantation in treating malignant obstructive jaundice (MOJ). Methods: The clinical data of 27 patients with proved MOJ, who were treated at authors' hospital during the period from 2016 to 2018, were retrospectively analyzed. Percutaneous transhepatic cholangial drainage (PTCD) under DSA monitoring was performed in all 27 patients, and implantation of self-expandable metal biliary stent and ¹²⁵I seed strip was carried out. The curative effect, the unobstructed time of stent, and the survival time of patients were assessed. Results: Successful procedure was accomplished in all patients. Excellent response was achieved in 18 patients and effective response in 9 patients. In 14 patients with cholangiocellular carcinoma, no significant difference in serum level of tumor marker CA199 existed between their preoperative value and postoperative one. As of last clinical follow-up of 17 patients, the patent time of stent was (10.1 ± 3.2) months. The median survival time in patients with high-position MOJ and in patients with low-position MOJ was 11 months and 10 months respectively. Conclusion: For the treatment of MOJ, biliary stenting combined with ¹²⁵I seed strip implantation is safe and effective, and the clinical jaundice can be quickly relieved. (authors)