Published March 1985 | Version v1
Journal article Metadata-only

On the problem of time, dose and fractionation (TDF) in the linear-quadratic model

Creators

  • 1. Sankt Marienkrankenhaus, Siegen (Germany, F.R.). Fachbereich Radiologie

Description

In many problems of modern radiotherapy such as multifractionation, interstitial and intracavitary therapy with implanats the NSD-formula is hardly applicable. Serious difficulties arise, when this formula is used for an estimation of late responses of tissues, because it mainly appreciates acute effects. On the basis of the linear-quadratic survival model S = exp(-αD-βD2) the TDF-problem is investigated with the help of kinetic principles. (orig.)

Abstract (German)

Die NSD-Formel ist auf viele Probleme der modernen Radiotherapie - wie z.B. Mehrfachfraktionierung, interstitielle und intrakavitaere Therapie mit Implantaten - kaum anwendbar. Ernsthafte Schwierigkeiten tauchen auf, wenn Spaetfolgen im Gewebe mit dieser Formel bewertet werden sollen, da die letztere hauptsaechlich fuer akute Reaktionen zutrifft. Das Problem der Bestrahlungsdauer, -dosis und Fraktionierung wird anhand des linear-quadratischen Ueberlebensmodells S = exp(-αD-βD2) nach den Regeln der Kinetik untersucht. (orig.)

Additional details

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
161
Journal Issue
3
Series
CODEN: STRAA.;Strahlentherapie.
Journal Page Range
177-185
ISSN
0039-2073

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
16057717
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
DELAYED RADIATION EFFECTS; DOSE RATES; EARLY RADIATION EFFECTS; EXTERNAL IRRADIATION; FRACTIONATED IRRADIATION; INTERNAL IRRADIATION; IRRADIATION PROCEDURES; LATENCY PERIOD; MATHEMATICAL MODELS; PLANNING; RADIATION DOSES; RADIATION INJURIES; RADIOTHERAPY; TIME DEPENDENCE
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DISEASES; INJURIES; IRRADIATION; MEDICINE; RADIATION EFFECTS; THERAPY