Published 1985
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Iodine-123-labeled pH shift brain-imaging agents
Description
HIPDM is an 123I-labeled agent with a distribution in brain reflecting regional perfusion. This compound is neutral and lipid soluble at blood pH and freely crosses the blood-brain barrier. At the lower pH in brain, it picks up a hydrogen ion and becomes positively charged. In this form the molecule is not lipid soluble and it is trapped in brain
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Additional details
Publishing Information
- Imprint Title
- Developing role of short-lived radionuclides in nuclear medical practice. DOE symposium series: 56
- Journal Page Range
- p. 320-333.
- Report number
- CONF-820523--
Conference
- Title
- International symposium on the developing role of short-lived radionuclides in nuclear medical practice.
- Dates
- 3-5 May 1982.
- Place
- Washington, DC (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17019266
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference, Numerical Data
- Descriptors DEI
- AMINES; AUTORADIOGRAPHY; BLOOD FLOW; BLOOD-BRAIN BARRIER; BRAIN; DIAGNOSIS; DISTRIBUTION; EXPERIMENTAL DATA; IODINE 123; PH VALUE; RADIOPHARMACEUTICALS; SELENIUM 75; TISSUES
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; DATA; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NERVOUS SYSTEM; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SELENIUM ISOTOPES