Published March 1983 | Version v1
Journal article Metadata-only

Mechanism of chromatin degradation in thymocytes of irradiated rats

Creators

  • 1. AN SSSR, Pushchino-na-Oke. Inst. Biologicheskoj Fiziki

Description

A biphase change in poly (ADP-ribose) polymerase activity of the thymocyte chromatin was observed after 10 Gy irradiation of rats: during the first minutes the incorporation of 14C-NAD increased by 40% then started decreasing to make 110, 60 and 35% after 1, 2 and 3 h, respectively. Irradiation of rat thymus chromatin in vitro sharply decreased poly (ADP-ribose) polymerase activity. The possible role of changes in the poly (ADP-ribose) synthesis in the activation of nuclear Ca/Mg-dependent endonuclease and in the postirradiation degradation of the thymocyte chromatin is discussed

Additional details

Additional titles

Subtitle (English)
Report 6. Postirradiation changes in poly (ADP-ribose) polymerase activity
Original title (Russian)
Механизм деградации хроматина в тимоцитах облученных крыс
Original subtitle (Russian)
Soobshchenie 6. Postradiatsionnye izmeneniya aktivnosti poli (ADF-ribozo)-polimerazy.

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
23
Journal Issue
2
Series
Radiobiologiya.
Journal Page Range
152-156
ISSN
0033-8192

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
14799029
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ADP; AMP; BIOLOGICAL RADIATION EFFECTS; CARBON 14 COMPOUNDS; CATALYSIS; CESIUM 137; CHROMATIN; DOSE-RESPONSE RELATIONSHIPS; IN VITRO; IN VIVO; MALES; METABOLISM; NAD; POLYMERASES; RATS; RIBOSE; THYMOCYTES
Descriptors DEC
ALDEHYDES; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CARBOHYDRATES; CARBON COMPOUNDS; CESIUM ISOTOPES; COENZYMES; ENZYMES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; MONOSACCHARIDES; NUCLEI; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PENTOSES; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; SACCHARIDES; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
For English translation see the journal Radiobiology (Translation) (USA).