Catalyst-free aldol reaction of N-substituted rhodanines on aqueous media

Rhodanine derivatives are highly valuable heterocycles in drug discovery. Here, we developed aldol reaction of N-substituted rhodanines and aromatic aldehydes on water. The reaction was performed at room temperature affording the products in good to high yield. This synthetic protocol uses simple experimental procedures, catalyst-free, and avoids the use of highly toxic solvents.

Graphical Abstract

SYNOPSIS Aldol reaction of N-substituted rhodanines and aromatic aldehydes on water at room temperature has been described. This protocol is simple, catalyst-free, and avoids the use of highly toxic solvents. .