Published 1988
| Version v1
Journal article
Factors influencing the adsorption of lutetium-177 on hydroxyapatite
Description
The in vitro adsorption of the osteotropic radioisotope 177Lu to hydroxyapatite was investigated. Adsorption was inhibited at low pH in the presence of a chelating acid (citrate) but not by acetate. The inhibition was caused by chelation of the Lu ion rather than acidity or solubilisation of the solid matrix, which also occurred under these conditions. Adsorption was not inhibited by Ca2+. The presence of chelating acids is predicted to be more important than low pH alone in inhibiting distribution in bone mineral in vivo. (author)
Additional details
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 15
- Journal Issue
- 5
- Series
- Nucl. Med. Biol.
- Journal Page Range
- 489-492
- ISSN
- 0883-2897
- CODEN
- NMBIE
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 20026904
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ACETATES; ADSORPTION; APATITES; CITRATES; HYDROXY COMPOUNDS; IN VITRO; INHIBITION; LUTETIUM 177; PH VALUE; RADIOPHARMACEUTICALS; SKELETON
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACID SALTS; DAYS LIVING RADIOISOTOPES; DRUGS; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LUTETIUM ISOTOPES; MATERIALS; MINERALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHOSPHATE MINERALS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RARE EARTH NUCLEI