Published 1994 | Version v1
Book Metadata-only

New TcO (N2S2) complexes as potential imaging agents

Creators

  • 1. Univ. of Pennsylvania, Philadelphia, PA (United States)

Description

Technetium is currently the most widely used radionuclide in diagnostic nuclear medicine. In developing new ligands which may provide improved properties for in vivo diagnostic imaging, a new N2S2 ligand with uneven N-H groups was prepared and the radiochemistry of the TcO(III) complexes were investigated. This new ligand system has an unique feature in that the neutral and lipid-soluble complex can be readily and reversible oxidized to a different neutral complex. The corresponding ReO(III) complexes are being prepared and investigated. The biological distribution in rats displayed high initial uptake in the brain

Additional details

Publishing Information

Publisher
American Chemical Society.
Imprint Place
Washington, DC (United States)
Imprint Title
208th ACS national meeting
Imprint Pagination
2072 p.
Journal Page Range
p. 1050, Paper MEDI 246.

Conference

Title
208. American Chemical Society national meeting.
Dates
21-26 Aug 1994.
Place
Washington, DC (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
26019624
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AMINES; CHEMICAL PREPARATION; LABELLING; RADIOPHARMACEUTICALS; TECHNETIUM COMPLEXES; TECHNETIUM OXIDES; THIOPHENOLS; TISSUE DISTRIBUTION
Descriptors DEC
CHALCOGENIDES; COMPLEXES; DISTRIBUTION; DRUGS; LABELLED COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; RADIOACTIVE MATERIALS; SYNTHESIS; TECHNETIUM COMPOUNDS; TRANSITION ELEMENT COMPLEXES; TRANSITION ELEMENT COMPOUNDS

Optional Information

Secondary number(s)
CONF-940813--.