Published 1983 | Version v1
Journal article Metadata-only

Independent induction of sister-chromatid exchanges by 3-aminobenzamide and ultraviolet radiation in HeLa cells

Creators

  • 1. Tokyo Univ. (Japan). Dept. of Physiological Chemistry

Description

The effect of 3-aminobenzamide in HeLa cells was examined in several aspects. 10-3 M 3-aminobenzamide inhibited poly(ADP-ribose) polymerase activity to more than 95% in disrupted nuclei of HeLa cells. The mode of inhibition of the enzyme was competitive inhibition with NAD at a Ksub(i) value of 2.5 μM 3-aminobenzamide. The combined treatment of HeLa cells with 3-aminobenzamide and ultraviolet radiation revealed the independent induction of SCEs by these 2 agents. (orig.)

Additional details

Publishing Information

Journal Title
Mutat. Res.
Journal Volume
107
Series
CODEN: MUREA.;Mutat. Res.
Journal Page Range
289-296
ISSN
0027-5107

INIS

Country of Publication
Netherlands
Country of Input or Organization
Netherlands
INIS RN
14778639
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
GENETIC RADIATION EFFECTS; HELA CELLS; SISTER CHROMATID EXCHANGES; ULTRAVIOLET RADIATION
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; MUTATIONS; RADIATION EFFECTS; RADIATIONS